Cell atlas - EDRF1 - The Human Protein Atlas

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EDRF1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol
	Nucleoplasm

Human cell
	Centrosome
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EDRF1
Gene description	Erythroid differentiation regulatory factor 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Centrosome (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031820
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & centrosome.

Main location

Nucleoplasm (approved)

Additional location

Centrosome (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031820	A-431	Nucleoplasm
			Centrosome
			Cytosol
	HPA031820	U-2 OS	Nucleoplasm
	HPA031820	U-2 OS	Cytosol
	HPA031820	U-251 MG	Nucleoplasm
	HPA031820	U-251 MG	Centrosome

GENE INFORMATION
Gene name	EDRF1 (HGNC Symbol)
Synonyms	C10orf137, DKFZp586F1019, FLJ21617
Description	Erythroid differentiation regulatory factor 1 (HGNC Symbol)
Entrez gene summary	This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	125719515 - 125764143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107938 (version 83.38)
Entrez gene	26098
UniProt	Q3B7T1 (UniProt - Evidence at protein level)
neXtProt	NX_Q3B7T1
Antibodypedia	EDRF1 antibodies

PROTEIN BROWSER

EDRF1-001	EDRF1-002	EDRF1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDRF1-001 ENSP00000336727 ENST00000337623	Q3B7T1 [Direct mapping] Erythroid differentiation-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1204 aa 134.9 kDa	No	0
EDRF1-002 ENSP00000357803 ENST00000368813	H0Y353 [Direct mapping] Erythroid differentiation-related factor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		317 aa 35.7 kDa	No	2
EDRF1-007 ENSP00000349244 ENST00000356792	Q3B7T1 [Direct mapping] Erythroid differentiation-related factor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1238 aa 138.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.