Expression of PITRM1 in cancer - Summary

CANCER ATLAS

Gene description

Pitrilysin metallopeptidase 1

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA006753	HPA006754

GENE INFORMATION
Gene name	PITRM1 (HGNC Symbol)
Synonyms	hMP1, KIAA1104, MP1, PreP
Description	Pitrilysin metallopeptidase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p15.2
Chromosome location (bp)	3137728 - 3172841
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107959 (version 83.38)
Entrez gene	10531
UniProt	Q5JRX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JRX3
Antibodypedia	PITRM1 antibodies

PROTEIN BROWSER

PITRM1-002	PITRM1-003	PITRM1-004	PITRM1-005	PITRM1-007	PITRM1-008	PITRM1-201	PITRM1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PITRM1-002 ENSP00000413687 ENST00000451454	H0Y7L7 [Direct mapping] Presequence protease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	259 aa 29.2 kDa	No	0
PITRM1-003 ENSP00000402072 ENST00000424714	B1APQ1 [Direct mapping] Presequence protease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.6 kDa	No	0
PITRM1-004 ENSP00000399307 ENST00000455371	B1APQ0 [Direct mapping] Presequence protease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	184 aa 20.2 kDa	No	0
PITRM1-005 ENSP00000391526 ENST00000430362	H0Y4F7 [Direct mapping] Presequence protease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	233 aa 26.4 kDa	No	0
PITRM1-007 ENSP00000224949 ENST00000224949	Q5JRX3 [Direct mapping] Presequence protease, mitochondrial Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006508 [proteolysis] GO:0008047 [enzyme activator activity] GO:0008270 [zinc ion binding] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] GO:0046872 [metal ion binding] Show all	1037 aa 117.4 kDa	No	0
PITRM1-008 ENSP00000370382 ENST00000380994	A0A0A0MRX9 [Direct mapping] Presequence protease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0006508 [proteolysis] GO:0046872 [metal ion binding] Show all	595 aa 67.1 kDa	No	0
PITRM1-201 ENSP00000370377 ENST00000380989	Q5JRX3 [Direct mapping] Presequence protease, mitochondrial Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006508 [proteolysis] GO:0008047 [enzyme activator activity] GO:0008270 [zinc ion binding] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] GO:0046872 [metal ion binding] Show all	1038 aa 117.5 kDa	No	0
PITRM1-202 ENSP00000401201 ENST00000451104	Q5JRX3 [Direct mapping] Presequence protease, mitochondrial Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004222 [metalloendopeptidase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006508 [proteolysis] GO:0008047 [enzyme activator activity] GO:0008270 [zinc ion binding] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] GO:0046872 [metal ion binding] Show all	939 aa 106.1 kDa	No	0