Cell atlas - EBF3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EBF3
Gene description	Early B-cell factor 3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (SCLC-21H, LHCN-M2, NB-4, RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA061169
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, LHCN-M2, NB-4, RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA061169	HEK 293	Nucleoplasm
HPA061169	RH-30	Nucleoplasm
HPA061169	RH-30	Vesicles
HPA061169	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	EBF3 (HGNC Symbol)
Synonyms	COE3, DKFZp667B0210
Description	Early B-cell factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	129835283 - 129963841
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108001 (version 83.38)
Entrez gene	253738
UniProt	Q9H4W6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4W6
Antibodypedia	EBF3 antibodies

PROTEIN BROWSER

EBF3-001	EBF3-002	EBF3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EBF3-001 ENSP00000347463 ENST00000355311	Q9H4W6 [Direct mapping] Transcription factor COE3 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] Show all	596 aa 64.9 kDa	No	0
EBF3-002 ENSP00000357637 ENST00000368648	Q9H4W6 [Direct mapping] Transcription factor COE3 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046983 [protein dimerization activity] Show all	551 aa 60.4 kDa	No	0
EBF3-004 ENSP00000387543 ENST00000440978	H0Y3W9 [Direct mapping] Transcription factor COE3 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	191 aa 19.4 kDa	No	0