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TFAM

CANCER ATLAS

Gene description

 Transcription factor A, mitochondrial

Protein class

 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040648

GENE INFORMATION

Gene name

 TFAM (HGNC Symbol)

Synonyms

 TCF6, TCF6L2

Description

 Transcription factor A, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 10

Cytoband

 q21.1

Chromosome location (bp)

 58385022 - 58399221

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108064 (version 83.38)

Entrez gene

 7019

UniProt

 Q00059 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00059

Antibodypedia

 TFAM antibodies

PROTEIN BROWSER
TFAM-001
TFAM-002
TFAM-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFAM-001
ENSP00000378776
ENST00000395377
H7BYN3 [Direct mapping]
Transcription factor A, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006338 [chromatin remodeling]
Show all
 219 aa
25.6 kDa 		No 0
TFAM-002
ENSP00000420588
ENST00000487519
Q00059 [Direct mapping]
Transcription factor A, mitochondrial
E5KSU5 [Target identity:100%; Query identity:100%]
Mitochondrial transcription factor A; Transcription factor A, mitochondrial, isoform CRA_c
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006261 [DNA-dependent DNA replication]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006390 [transcription from mitochondrial promoter]
GO:0006391 [transcription initiation from mitochondrial promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008301 [DNA binding, bending]
GO:0010467 [gene expression]
GO:0031072 [heat shock protein binding]
GO:0033108 [mitochondrial respiratory chain complex assembly]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070363 [mitochondrial light strand promoter sense binding]
Show all
 246 aa
29.1 kDa 		Yes 0
TFAM-004
ENSP00000363002
ENST00000373895
Q00059 [Direct mapping]
Transcription factor A, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006261 [DNA-dependent DNA replication]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006390 [transcription from mitochondrial promoter]
GO:0006391 [transcription initiation from mitochondrial promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008301 [DNA binding, bending]
GO:0010467 [gene expression]
GO:0042645 [mitochondrial nucleoid]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070363 [mitochondrial light strand promoter sense binding]
Show all
 214 aa
25.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.