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UBE2S

GENERAL INFORMATION

Gene name

 UBE2S

Gene description

 Ubiquitin-conjugating enzyme E2S

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in seminiferous ducts and a subset of cells in squamous epithelia, urinary bladder and lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA057150 , CAB015228
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Vagina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2S (HGNC Symbol)

Synonyms

 E2-EPF

Description

 Ubiquitin-conjugating enzyme E2S (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55399745 - 55407777

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108106 (version 83.38)

Entrez gene

 27338

UniProt

 Q16763 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16763

Antibodypedia

 UBE2S antibodies

PROTEIN BROWSER
UBE2S-001
UBE2S-002
UBE2S-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2S-001
ENSP00000264552
ENST00000264552
Q16763 [Direct mapping]
Ubiquitin-conjugating enzyme E2 S
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005524 [ATP binding]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035519 [protein K29-linked ubiquitination]
GO:0044314 [protein K27-linked ubiquitination]
GO:0051301 [cell division]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
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 222 aa
23.8 kDa 		No 0
UBE2S-002
ENSP00000467409
ENST00000587845
K7EPJ1 [Direct mapping]
Ubiquitin-conjugating enzyme E2 S
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
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 204 aa
22.4 kDa 		No 0
UBE2S-003
ENSP00000466388
ENST00000589978
K7EM75 [Direct mapping]
Ubiquitin-conjugating enzyme E2 S
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 79 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.