Fields »
ABOUT
HELP
BLOG
PPIF

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PPIF

Gene description

 Peptidylprolyl isomerase F

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA077416
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA077416 A-431 Mitochondria
HPA077416 CACO-2 Mitochondria
HPA077416 U-2 OS Mitochondria

GENE INFORMATION

Gene name

 PPIF (HGNC Symbol)

Synonyms

 Cyp-D, hCyP3

Description

 Peptidylprolyl isomerase F (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.3

Chromosome location (bp)

 79347469 - 79355337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108179 (version 83.38)

Entrez gene

 10105

UniProt

 P30405 (UniProt - Evidence at protein level)

neXtProt

 NX_P30405

Antibodypedia

 PPIF antibodies

PROTEIN BROWSER
PPIF-001
PPIF-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIF-001
ENSP00000225174
ENST00000225174
P30405 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
A0A024QZS4 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002931 [response to ischemia]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006979 [response to oxidative stress]
GO:0008637 [apoptotic mitochondrial changes]
GO:0010849 [regulation of proton-transporting ATPase activity, rotational mechanism]
GO:0010939 [regulation of necrotic cell death]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0042277 [peptide binding]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0070266 [necroptotic process]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0071277 [cellular response to calcium ion]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:1902445 [regulation of mitochondrial membrane permeability involved in programmed necrotic cell death]
GO:2000276 [negative regulation of oxidative phosphorylation uncoupler activity]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 207 aa
22 kDa 		No 0
PPIF-004
ENSP00000396388
ENST00000448165
H0Y548 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0008637 [apoptotic mitochondrial changes]
Show all
 165 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.