Expression of FBXL20 in cancer - Summary

CANCER ATLAS

Gene description

F-box and leucine-rich repeat protein 20

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA044748	HPA050397

GENE INFORMATION
Gene name	FBXL20 (HGNC Symbol)
Synonyms	Fbl2, Fbl20, MGC15482
Description	F-box and leucine-rich repeat protein 20 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39252644 - 39402523
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108306 (version 83.38)
Entrez gene	84961
UniProt	Q96IG2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IG2
Antibodypedia	FBXL20 antibodies

PROTEIN BROWSER

FBXL20-001	FBXL20-002	FBXL20-003	FBXL20-004	FBXL20-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL20-001 ENSP00000264658 ENST00000264658	Q96IG2 [Direct mapping] F-box/LRR-repeat protein 20 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001662 [behavioral fear response] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	436 aa 48.4 kDa	No	0
FBXL20-002 ENSP00000377832 ENST00000394294	Q96IG2 [Direct mapping] F-box/LRR-repeat protein 20 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	404 aa 45 kDa	No	0
FBXL20-003 ENSP00000462271 ENST00000583610	Q96IG2 [Direct mapping] F-box/LRR-repeat protein 20 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	436 aa 48.4 kDa	No	0
FBXL20-004 ENSP00000462878 ENST00000577399	J3KTA1 [Direct mapping] F-box and leucine-rich repeat protein 20, isoform CRA_a; F-box/LRR-repeat protein 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	438 aa 48.6 kDa	No	0
FBXL20-005 ENSP00000463132 ENST00000581781	J3QKL3 [Direct mapping] F-box/LRR-repeat protein 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13 kDa	No	0