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CSF3

GENERAL INFORMATION

Gene name

 CSF3

Gene description

 Colony stimulating factor 3 (granulocyte)

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, appendix)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (lung, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels, most abundant in exocrine pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA001412 , CAB016131
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, skeletal muscle)

GENE INFORMATION

Gene name

 CSF3 (HGNC Symbol)

Synonyms

 C17orf33, G-CSF, GCSF, MGC45931

Description

 Colony stimulating factor 3 (granulocyte) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Chromosome

 17

Cytoband

 q21.1

Chromosome location (bp)

 40015361 - 40017813

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108342 (version 83.38)

Entrez gene

 1440

UniProt

 P09919 (UniProt - Evidence at protein level)

neXtProt

 NX_P09919

Antibodypedia

 CSF3 antibodies

PROTEIN BROWSER
CSF3-001
CSF3-002
CSF3-003
CSF3-004
CSF3-006
CSF3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSF3-001
ENSP00000225474
ENST00000225474
P09919 [Direct mapping]
Granulocyte colony-stimulating factor
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005130 [granulocyte colony-stimulating factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030851 [granulocyte differentiation]
GO:0032092 [positive regulation of protein binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:1901215 [negative regulation of neuron death]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
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 207 aa
22.3 kDa 		Yes 0
CSF3-002
ENSP00000327766
ENST00000331769
Q8N4W3 [Direct mapping]
Colony stimulating factor 3 (Granulocyte); Colony stimulating factor 3 (Granulocyte), isoform CRA_a; Granulocyte colony-stimulating factor; cDNA FLJ76606, highly similar to Homo sapiens colony stimulating factor 3 (granulocyte) (CSF3), transcript variant 3, mRNA
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
Show all
 200 aa
21.5 kDa 		Yes 0
CSF3-003
ENSP00000377705
ENST00000394149
P09919 [Direct mapping]
Granulocyte colony-stimulating factor
Q6FH65 [Target identity:100%; Query identity:100%]
CSF3 protein; Colony stimulating factor 3 (Granulocyte), isoform CRA_c; cDNA, FLJ94067, Homo sapiens colony stimulating factor 3 (granulocyte) (CSF3),transcript variant 2, mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005130 [granulocyte colony-stimulating factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030851 [granulocyte differentiation]
GO:0032092 [positive regulation of protein binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0071345 [cellular response to cytokine stimulus]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 204 aa
22 kDa 		Yes 0
CSF3-004
ENSP00000377704
ENST00000394148
P09919 [Direct mapping]
Granulocyte colony-stimulating factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005130 [granulocyte colony-stimulating factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030851 [granulocyte differentiation]
GO:0032092 [positive regulation of protein binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0071345 [cellular response to cytokine stimulus]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 171 aa
18.4 kDa 		Yes 0
CSF3-006
ENSP00000462991
ENST00000577675
J3KTH8 [Direct mapping]
Granulocyte colony-stimulating factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
Show all
 164 aa
17.7 kDa 		Yes 0
CSF3-008
ENSP00000464421
ENST00000583218
J3QRX2 [Direct mapping]
Granulocyte colony-stimulating factor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
Show all
 155 aa
16.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.