Expression of RGS9 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Regulator of G-protein signaling 9

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014137

GENE INFORMATION
Gene name	RGS9 (HGNC Symbol)
Synonyms	MGC111763, MGC26458, PERRS, RGS9L
Description	Regulator of G-protein signaling 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	q24.1
Chromosome location (bp)	65137431 - 65227703
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108370 (version 83.38)
Entrez gene	8787
UniProt	O75916 (UniProt - Evidence at protein level)
neXtProt	NX_O75916
Antibodypedia	RGS9 antibodies

PROTEIN BROWSER

RGS9-002	RGS9-003	RGS9-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGS9-002 ENSP00000396329 ENST00000449996	O75916 [Direct mapping] Regulator of G-protein signaling 9 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005737 [cytoplasm] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0035556 [intracellular signal transduction] Show all	671 aa 76.6 kDa	No	0
RGS9-003 ENSP00000262406 ENST00000262406	O75916 [Direct mapping] Regulator of G-protein signaling 9 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0004871 [signal transducer activity] GO:0005096 [GTPase activator activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007212 [dopamine receptor signaling pathway] GO:0007399 [nervous system development] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0032403 [protein complex binding] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0043627 [response to estrogen] Show all	674 aa 77 kDa	No	0
RGS9-007 ENSP00000405814 ENST00000443584	E9PD91 [Direct mapping] Regulator of G-protein-signaling 9 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005737 [cytoplasm] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0035556 [intracellular signal transduction] Show all	628 aa 72 kDa	No	0