Expression of DHX40 in cancer - Summary

CANCER ATLAS

Gene description

DEAH (Asp-Glu-Ala-His) box polypeptide 40

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044350

GENE INFORMATION
Gene name	DHX40 (HGNC Symbol)
Synonyms	ARG147, DDX40, FLJ22060, PAD
Description	DEAH (Asp-Glu-Ala-His) box polypeptide 40 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]
Chromosome	17
Cytoband	q23.1
Chromosome location (bp)	59565525 - 59608345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108406 (version 83.38)
Entrez gene	79665
UniProt	Q8IX18 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IX18
Antibodypedia	DHX40 antibodies

PROTEIN BROWSER

DHX40-001	DHX40-002	DHX40-007	DHX40-009	DHX40-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHX40-001 ENSP00000251241 ENST00000251241	Q8IX18 [Direct mapping] Probable ATP-dependent RNA helicase DHX40 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] Show all	779 aa 88.6 kDa	No	0
DHX40-002 ENSP00000388749 ENST00000425628	Q8IX18 [Direct mapping] Probable ATP-dependent RNA helicase DHX40 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] Show all	702 aa 80.2 kDa	No	0
DHX40-007 ENSP00000437958 ENST00000538926	F5H625 [Direct mapping] Probable ATP-dependent RNA helicase DHX40 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0044822 [poly(A) RNA binding] Show all	250 aa 27.9 kDa	No	0
DHX40-009 ENSP00000463025 ENST00000584385	J3KTK0 [Direct mapping] Probable ATP-dependent RNA helicase DHX40 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] Show all	173 aa 19.3 kDa	No	0
DHX40-010 ENSP00000462686 ENST00000580030	J3KSW6 [Direct mapping] Probable ATP-dependent RNA helicase DHX40 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] Show all	268 aa 30 kDa	No	0