Cell atlas - PIGL - The Human Protein Atlas

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PIGL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PIGL
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class L
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA012739
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012739	A-431	Nucleoplasm	Spatial
	HPA012739	A-431	Cytosol	Spatial
	HPA012739	U-2 OS	Nucleoplasm	Spatial
	HPA012739	U-2 OS	Cytosol	Spatial
	HPA012739	U-251 MG	Nucleoplasm	Spatial
	HPA012739	U-251 MG	Cytosol	Spatial

GENE INFORMATION
Gene name	PIGL
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class L (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	16217191 - 16351797
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108474 (version 83.38)
Entrez gene	9487
UniProt	Q9Y2B2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2B2
Antibodypedia	PIGL antibodies

PROTEIN BROWSER

PIGL-001	PIGL-003	PIGL-005	PIGL-010	PIGL-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGL-001 ENSP00000225609 ENST00000225609	Q9Y2B2 [Direct mapping] N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000225 [N-acetylglucosaminylphosphatidylinositol deacetylase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	252 aa 28.5 kDa	Yes	0
PIGL-003 ENSP00000485657 ENST00000463810	A0A096LPK2 [Direct mapping] N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.3 kDa	Yes	0
PIGL-005 ENSP00000379185 ENST00000395844	A8MTV0 [Direct mapping] N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		244 aa 26.8 kDa	Yes	0
PIGL-010 ENSP00000463540 ENST00000584797	J3QLG8 [Direct mapping] N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 20.9 kDa	Yes	0
PIGL-012 ENSP00000462432 ENST00000581006	J3KSD1 [Direct mapping] N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 17.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.