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ENO3

CANCER ATLAS

Gene description

 Enolase 3 (beta, muscle)

Protein class

 Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA000793

GENE INFORMATION

Gene name

 ENO3

Synonyms

Description

 Enolase 3 (beta, muscle) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4948092 - 4957131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108515 (version 83.38)

Entrez gene

 2027

UniProt

 P13929 (UniProt - Evidence at protein level)

neXtProt

 NX_P13929

Antibodypedia

 ENO3 antibodies

PROTEIN BROWSER
ENO3-001
ENO3-005
ENO3-006
ENO3-007
ENO3-008
ENO3-009
ENO3-010
ENO3-012
ENO3-018
ENO3-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENO3-001
ENSP00000324105
ENST00000323997
P13929 [Direct mapping]
Beta-enolase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0007568 [aging]
GO:0016020 [membrane]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47 kDa 		No 0
ENO3-005
ENSP00000430636
ENST00000519584
P13929 [Direct mapping]
Beta-enolase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 391 aa
42.2 kDa 		No 0
ENO3-006
ENSP00000431087
ENST00000518175
P13929 [Direct mapping]
Beta-enolase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47 kDa 		No 0
ENO3-007
ENSP00000467270
ENST00000519266
K7EP84 [Direct mapping]
Beta-enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 28 aa
3.2 kDa 		No 0
ENO3-008
ENSP00000428502
ENST00000522798
E5RI09 [Direct mapping]
Beta-enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 148 aa
15.8 kDa 		No 0
ENO3-009
ENSP00000465697
ENST00000522301
K7EKN2 [Direct mapping]
Enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 212 aa
22.5 kDa 		No 0
ENO3-010
ENSP00000430055
ENST00000519602
E5RGZ4 [Direct mapping]
Enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
GO:0021762 [substantia nigra development]
Show all
 283 aa
30.4 kDa 		No 0
ENO3-012
ENSP00000428811
ENST00000522249
E5RG95 [Direct mapping]
Beta-enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 154 aa
16.5 kDa 		No 0
ENO3-018
ENSP00000464874
ENST00000521811
E5RI09 [Direct mapping]
Beta-enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 148 aa
15.8 kDa 		No 0
ENO3-019
ENSP00000467444
ENST00000520221
K7EPM1 [Direct mapping]
Enolase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 196 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.