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RASD1

CANCER ATLAS

Gene description

 RAS, dexamethasone-induced 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047896

GENE INFORMATION

Gene name

 RASD1 (HGNC Symbol)

Synonyms

 AGS1, DEXRAS1

Description

 RAS, dexamethasone-induced 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 17494437 - 17496395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108551 (version 83.38)

Entrez gene

 51655

UniProt

 Q9Y272 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y272

Antibodypedia

 RASD1 antibodies

PROTEIN BROWSER
RASD1-001
RASD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASD1-001
ENSP00000225688
ENST00000225688
Q9Y272 [Direct mapping]
Dexamethasone-induced Ras-related protein 1
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Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 281 aa
31.6 kDa 		No 0
RASD1-002
ENSP00000463388
ENST00000579152
Q9Y272 [Direct mapping]
Dexamethasone-induced Ras-related protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 122 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.