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ALDH3A1

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GENERAL INFORMATION

Gene name

 ALDH3A1

Gene description

 Aldehyde dehydrogenase 3 family, member A1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.

RNA cell category

 Cell line enriched (A549)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

Additional location

 In addition localized to the Vesicles (approved), Plasma membrane (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA051150 , HPA063783
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (A549)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.

Main location

 Cytosol (validated)

Additional location

 Vesicles (approved), Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051150 A549 Plasma membrane Intensity
Cytosol
HPA063783 A549 Nucleoplasm
Vesicles Intensity
Cytosol Intensity
HPA063783 U-2 OS No staining    

GENE INFORMATION

Gene name

 ALDH3A1 (HGNC Symbol)

Synonyms

 ALDH3

Description

 Aldehyde dehydrogenase 3 family, member A1 (HGNC Symbol)

Entrez gene summary

 Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 19737984 - 19748943

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108602 (version 83.38)

Entrez gene

 218

UniProt

 P30838 (UniProt - Evidence at protein level)

neXtProt

 NX_P30838

Antibodypedia

 ALDH3A1 antibodies

PROTEIN BROWSER
ALDH3A1-001
ALDH3A1-005
ALDH3A1-007
ALDH3A1-009
ALDH3A1-010
ALDH3A1-013
ALDH3A1-014
ALDH3A1-016
ALDH3A1-018
ALDH3A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH3A1-001
ENSP00000225740
ENST00000225740
P30838 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008106 [alcohol dehydrogenase (NADP+) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 453 aa
50.4 kDa 		No 0
ALDH3A1-005
ENSP00000460482
ENST00000494157
I3L3I9 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 380 aa
41.9 kDa 		No 0
ALDH3A1-007
ENSP00000378923
ENST00000395555
A8MYB8 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 389 aa
43.3 kDa 		No 0
ALDH3A1-009
ENSP00000389766
ENST00000439102
C9JMC5 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 372 aa
41.6 kDa 		No 0
ALDH3A1-010
ENSP00000411821
ENST00000457500
P30838 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008106 [alcohol dehydrogenase (NADP+) activity]
GO:0008152 [metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0014070 [response to organic cyclic compound]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0051384 [response to glucocorticoid]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
Show all
 453 aa
50.4 kDa 		No 0
ALDH3A1-013
ENSP00000458841
ENST00000574162
I3L1H6 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 131 aa
15 kDa 		No 0
ALDH3A1-014
ENSP00000460792
ENST00000570414
I3L3W9 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 74 aa
8.7 kDa 		No 0
ALDH3A1-016
ENSP00000461189
ENST00000573368
I3L4E5 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 120 aa
14 kDa 		No 0
ALDH3A1-018
ENSP00000388369
ENST00000426645
C9JKT2 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 259 aa
29.1 kDa 		No 0
ALDH3A1-201
ENSP00000388469
ENST00000444455
P30838 [Direct mapping]
Aldehyde dehydrogenase, dimeric NADP-preferring
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008106 [alcohol dehydrogenase (NADP+) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 453 aa
50.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.