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Aldehyde dehydrogenase 3 family, member A1 (HGNC Symbol)
Entrez gene summary
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006081 [cellular aldehyde metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0008106 [alcohol dehydrogenase (NADP+) activity] GO:0008152 [metabolic process] GO:0008284 [positive regulation of cell proliferation] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0042493 [response to drug] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0051384 [response to glucocorticoid] GO:0051591 [response to cAMP] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)