Cell atlas - SMARCD2 - The Human Protein Atlas

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SMARCD2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SMARCD2
Gene description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA059934 , HPA061348
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059934	HEK 293	Nucleoplasm
	HPA059934	MCF7	Nucleoplasm
	HPA059934	U-2 OS	Nucleoplasm
	HPA061348	HEK 293	Nucleoplasm
	HPA061348	MCF7	Nucleoplasm
	HPA061348	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	SMARCD2 (HGNC Symbol)
Synonyms	BAF60B, CRACD2, PRO2451, Rsc6p
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63832081 - 63843065
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108604 (version 83.38)
Entrez gene	6603
UniProt	Q92925 (UniProt - Evidence at protein level)
neXtProt	NX_Q92925
Antibodypedia	SMARCD2 antibodies

PROTEIN BROWSER

SMARCD2-001	SMARCD2-002	SMARCD2-003	SMARCD2-005	SMARCD2-012	SMARCD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMARCD2-001 ENSP00000392617 ENST00000448276	Q92925 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016514 [SWI/SNF complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0090544 [BAF-type complex] Show all	531 aa 58.9 kDa	No	0
SMARCD2-002 ENSP00000225742 ENST00000225742	J3KMX2 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016514 [SWI/SNF complex] GO:0043044 [ATP-dependent chromatin remodeling] Show all	456 aa 52.2 kDa	No	0
SMARCD2-003 ENSP00000318451 ENST00000323347	Q92925 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016514 [SWI/SNF complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] Show all	483 aa 55.2 kDa	No	0
SMARCD2-005 ENSP00000462761 ENST00000577990	J3KT18 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 6 kDa	No	0
SMARCD2-012 ENSP00000398946 ENST00000450364	J3QWB6 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016514 [SWI/SNF complex] GO:0043044 [ATP-dependent chromatin remodeling] Show all	231 aa 26.7 kDa	No	0
SMARCD2-201 ENSP00000483605 ENST00000613943	B9EGA3 [Direct mapping] SMARCD2 protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016514 [SWI/SNF complex] GO:0043044 [ATP-dependent chromatin remodeling] Show all	494 aa 55.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.