Cell atlas - UTP6 - The Human Protein Atlas

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UTP6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	UTP6
Gene description	UTP6, small subunit (SSU) processome component, homolog (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA025936 , HPA055806
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA025936	A-431	Nucleoli
HPA025936	U-2 OS	Nucleoli
HPA025936	U-251 MG	Nucleoli
HPA055806	U-2 OS	Nucleoli

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA025936

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

71%

p-value

< 0.01

Relative fluorescence intensity (RFI)

Antibody

HPA055806

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

12%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA025936	siRNA 1	U-2 OS
HPA025936	scrambled	U-2 OS
HPA055806	siRNA 1	U-2 OS
HPA055806	scrambled	U-2 OS

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000035575 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055806	NIH 3T3	No staining

GENE INFORMATION
Gene name	UTP6 (HGNC Symbol)
Synonyms	C17orf40, HCA66
Description	UTP6, small subunit (SSU) processome component, homolog (yeast) (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	31860899 - 31901765
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108651 (version 83.38)
Entrez gene	55813
UniProt	Q9NYH9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYH9
Antibodypedia	UTP6 antibodies

PROTEIN BROWSER

UTP6-001	UTP6-007	UTP6-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UTP6-001 ENSP00000261708 ENST00000261708	Q9NYH9 [Direct mapping] U3 small nucleolar RNA-associated protein 6 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005622 [intracellular] GO:0005730 [nucleolus] GO:0006396 [RNA processing] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome] Show all	597 aa 70.2 kDa	No	0
UTP6-007 ENSP00000462135 ENST00000581012	J3KRR8 [Direct mapping] U3 small nucleolar RNA-associated protein 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome] Show all	61 aa 6.9 kDa	No	0
UTP6-008 ENSP00000464599 ENST00000579459	J3QSA7 [Direct mapping] U3 small nucleolar RNA-associated protein 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome] Show all	29 aa 3.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.