Expression of DDX5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

DEAD (Asp-Glu-Ala-Asp) box helicase 5

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA020043	CAB005868

GENE INFORMATION
Gene name	DDX5 (HGNC Symbol)
Synonyms	G17P1, HLR1, p68
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 5 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	64499616 - 64508199
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108654 (version 83.38)
Entrez gene	1655
UniProt	P17844 (UniProt - Evidence at protein level)
neXtProt	NX_P17844
Antibodypedia	DDX5 antibodies

PROTEIN BROWSER

DDX5-001	DDX5-005	DDX5-006	DDX5-007	DDX5-008	DDX5-009	DDX5-010	DDX5-011	DDX5-012	DDX5-013	DDX5-014	DDX5-015	DDX5-019	DDX5-026	DDX5-027	DDX5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX5-001 ENSP00000225792 ENST00000225792	P17844 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0001701 [in utero embryonic development] GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0007623 [circadian rhythm] GO:0009299 [mRNA transcription] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0019899 [enzyme binding] GO:0030331 [estrogen receptor binding] GO:0030529 [ribonucleoprotein complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0036002 [pre-mRNA binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044822 [poly(A) RNA binding] GO:0045069 [regulation of viral genome replication] GO:0045667 [regulation of osteoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048306 [calcium-dependent protein binding] GO:0050681 [androgen receptor binding] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:2001014 [regulation of skeletal muscle cell differentiation] Show all	614 aa 69.1 kDa	No	0
DDX5-005 ENSP00000462885 ENST00000578804	J3KTA4 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0010501 [RNA secondary structure unwinding] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	614 aa 69.1 kDa	No	0
DDX5-006 ENSP00000403085 ENST00000450599	P17844 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0009299 [mRNA transcription] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030331 [estrogen receptor binding] GO:0030529 [ribonucleoprotein complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0036002 [pre-mRNA binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044822 [poly(A) RNA binding] GO:0045667 [regulation of osteoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050681 [androgen receptor binding] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:2001014 [regulation of skeletal muscle cell differentiation] Show all	535 aa 60.6 kDa	No	0
DDX5-007 ENSP00000464659 ENST00000579996	J3QSF1 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	153 aa 17.9 kDa	No	0
DDX5-008 ENSP00000463168 ENST00000585111	J3QKN9 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	44 aa 4.7 kDa	No	0
DDX5-009 ENSP00000464064 ENST00000581806	J3QR62 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	52 aa 5.5 kDa	No	0
DDX5-010 ENSP00000464337 ENST00000577922	J3QRQ7 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0010501 [RNA secondary structure unwinding] Show all	212 aa 23.5 kDa	No	0
DDX5-011 ENSP00000462206 ENST00000584279	J3KRX8 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	120 aa 13.7 kDa	No	0
DDX5-012 ENSP00000464304 ENST00000581697	J3QRN5 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	65 aa 6.9 kDa	No	0
DDX5-013 ENSP00000463101 ENST00000583239	J3KTQ4 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	38 aa 3.9 kDa	No	0
DDX5-014 ENSP00000464587 ENST00000579091	J3QS97 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	31 aa 3.3 kDa	No	0
DDX5-015 ENSP00000463903 ENST00000583212	A0A0G2JLI4 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	10 aa 1.2 kDa	No	0
DDX5-019 ENSP00000462222 ENST00000577787	J3KRZ1 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	166 aa 18.9 kDa	No	0
DDX5-026 ENSP00000465791 ENST00000585060	K7EKV0 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	16 aa 1.8 kDa	No	0
DDX5-027 ENSP00000463541 ENST00000578190	J3QLG9 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	46 aa 4.8 kDa	No	0
DDX5-201 ENSP00000485764 ENST00000630471	J3QR02 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0010501 [RNA secondary structure unwinding] Show all	99 aa 11.4 kDa	No	0