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The majority of cancers showed moderate to strong cytoplasmic staining. Nucleolar positivity was observed in several cases. Malignant gliomas, lymphomas and melanomas along with testicular and renal cancers were negative.
GENE INFORMATION
Gene name
ASIC2 (HGNC Symbol)
Synonyms
ACCN, ACCN1, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG
Description
Acid sensing (proton gated) ion channel 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]