Tissue expression of CCL7 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCL7
Gene description	Chemokine (C-C motif) ligand 7
Protein class	Cancer-related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (bone marrow, appendix)
GTEx:	Tissue enhanced (lung, fallopian tube)
FANTOM5:	Tissue enriched (adipose tissue)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (bone marrow, appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, fallopian tube)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adipose tissue)

GENE INFORMATION
Gene name	CCL7 (HGNC Symbol)
Synonyms	FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
Description	Chemokine (C-C motif) ligand 7 (HGNC Symbol)
Entrez gene summary	This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	34270221 - 34272242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108688 (version 83.38)
Entrez gene	6354
UniProt	P80098 (UniProt - Evidence at protein level)
neXtProt	NX_P80098
Antibodypedia	CCL7 antibodies

PROTEIN BROWSER

CCL7-001	CCL7-002	CCL7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCL7-001 ENSP00000367832 ENST00000378569	P80098 [Direct mapping] C-C motif chemokine 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002548 [monocyte chemotaxis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0006874 [cellular calcium ion homeostasis] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007010 [cytoskeleton organization] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008009 [chemokine activity] GO:0008201 [heparin binding] GO:0008360 [regulation of cell shape] GO:0010332 [response to gamma radiation] GO:0030335 [positive regulation of cell migration] GO:0030593 [neutrophil chemotaxis] GO:0031726 [CCR1 chemokine receptor binding] GO:0031727 [CCR2 chemokine receptor binding] GO:0043547 [positive regulation of GTPase activity] GO:0048245 [eosinophil chemotaxis] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071361 [cellular response to ethanol] GO:2000503 [positive regulation of natural killer cell chemotaxis] Show all	99 aa 11.2 kDa	Yes	0
CCL7-002 ENSP00000378126 ENST00000394630	A8MX17 [Direct mapping] C-C motif chemokine 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		47 aa 5 kDa	Yes	0
CCL7-003 ENSP00000378124 ENST00000394627	A8MVH1 [Direct mapping] C-C motif chemokine 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		81 aa 8.6 kDa	Yes	1