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CCL8

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GENERAL INFORMATION

Gene name

 CCL8

Gene description

 Chemokine (C-C motif) ligand 8

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CCL8 (HGNC Symbol)

Synonyms

 HC14, MCP-2, SCYA8

Description

 Chemokine (C-C motif) ligand 8 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 34319036 - 34321402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108700 (version 83.38)

Entrez gene

 6355

UniProt

 P80075 (UniProt - Evidence at protein level)

neXtProt

 NX_P80075

Antibodypedia

 CCL8 antibodies

PROTEIN BROWSER
CCL8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL8-001
ENSP00000378118
ENST00000394620
P80075 [Direct mapping]
C-C motif chemokine 8 MCP-2(6-76)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0001525 [angiogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0002687 [positive regulation of leukocyte migration]
GO:0004672 [protein kinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0009615 [response to virus]
GO:0016004 [phospholipase activator activity]
GO:0030593 [neutrophil chemotaxis]
GO:0031727 [CCR2 chemokine receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070664 [negative regulation of leukocyte proliferation]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 99 aa
11.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.