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A majority of colorectal cancers and several ovarian, pancreatic and gastric cancers showed moderate cytoplasmic and/or membranous staining. Most other cancer cells were weakly stained or negative.
Papillary adenocarcinomas of thyroid displayed moderate to strong cytoplasmic immunoreactivity. A few cases of melanomas and ovarian cancers showed moderate staining. Most remaining cancers were weakly stained or negative.
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0009615 [response to virus] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0039534 [negative regulation of MDA-5 signaling pathway] GO:0039536 [negative regulation of RIG-I signaling pathway] GO:0045087 [innate immune response] GO:0045088 [regulation of innate immune response] GO:0045824 [negative regulation of innate immune response] GO:0051607 [defense response to virus] GO:1900245 [positive regulation of MDA-5 signaling pathway] GO:1900246 [positive regulation of RIG-I signaling pathway]
