Expression of MRPL27 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L27

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA021416

GENE INFORMATION
Gene name	MRPL27
Synonyms
Description	Mitochondrial ribosomal protein L27 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50367857 - 50373214
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108826 (version 83.38)
Entrez gene	51264
UniProt	Q9P0M9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0M9
Antibodypedia	MRPL27 antibodies

PROTEIN BROWSER

MRPL27-001	MRPL27-002	MRPL27-003	MRPL27-004	MRPL27-005	MRPL27-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL27-001 ENSP00000225969 ENST00000225969	Q9P0M9 [Direct mapping] 39S ribosomal protein L27, mitochondrial Show all	Ribosomal proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	148 aa 16.1 kDa	Yes	0
MRPL27-002 ENSP00000388915 ENST00000442592	B3KN43 [Direct mapping] 39S ribosomal protein L27, mitochondrial; Mitochondrial ribosomal protein L27, isoform CRA_a; cDNA FLJ13514 fis, clone PLACE1005557, highly similar to Homo sapiens mitochondrial ribosomal protein L27 (MRPL27), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	94 aa 9.9 kDa	Yes	0
MRPL27-003 ENSP00000425126 ENST00000503633	D6RE11 [Direct mapping] 39S ribosomal protein L27, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	84 aa 9.2 kDa	Yes	0
MRPL27-004 ENSP00000421865 ENST00000507088	D6RAN8 [Direct mapping] 39S ribosomal protein L27, mitochondrial; Mitochondrial ribosomal protein L27, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	93 aa 10.5 kDa	No	0
MRPL27-005 ENSP00000426037 ENST00000511860	D6RAN8 [Direct mapping] 39S ribosomal protein L27, mitochondrial; Mitochondrial ribosomal protein L27, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	93 aa 10.5 kDa	No	0
MRPL27-007 ENSP00000424321 ENST00000508200	H7C5U8 [Direct mapping] 39S ribosomal protein L27, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	136 aa 14.7 kDa	No	0