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HDAC5

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GENERAL INFORMATION

Gene name

 HDAC5

Gene description

 Histone deacetylase 5

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol & the Golgi apparatus.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

Additional location

 In addition localized to the Golgi apparatus (approved), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA030991
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol & the Golgi apparatus.

Main location

 Nuclear speckles (supported)

Additional location

 Golgi apparatus (approved), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA030991 A-431 Nuclear speckles
Golgi apparatus
Cytosol
HPA030991 U-2 OS Nuclear speckles
Cytosol
HPA030991 U-251 MG Nuclear speckles
Golgi apparatus
Cytosol

GENE INFORMATION

Gene name

 HDAC5 (HGNC Symbol)

Synonyms

 FLJ90614, KIAA0600, NY-CO-9

Description

 Histone deacetylase 5 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 44076746 - 44123702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108840 (version 83.38)

Entrez gene

 10014

UniProt

 Q9UQL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQL6

Antibodypedia

 HDAC5 antibodies

PROTEIN BROWSER
HDAC5-001
HDAC5-002
HDAC5-003
HDAC5-007
HDAC5-008
HDAC5-009
HDAC5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC5-001
ENSP00000337290
ENST00000336057
Q9UQL6 [Direct mapping]
Histone deacetylase 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001025 [RNA polymerase III transcription factor binding]
GO:0001047 [core promoter binding]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0010830 [regulation of myotube differentiation]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0043393 [regulation of protein binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
Show all
 1037 aa
112.2 kDa 		No 0
HDAC5-002
ENSP00000468004
ENST00000586802
Q9UQL6 [Direct mapping]
Histone deacetylase 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001025 [RNA polymerase III transcription factor binding]
GO:0001047 [core promoter binding]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0010830 [regulation of myotube differentiation]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0043393 [regulation of protein binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
Show all
 1122 aa
122 kDa 		No 0
HDAC5-003
ENSP00000225983
ENST00000225983
Q9UQL6 [Direct mapping]
Histone deacetylase 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001025 [RNA polymerase III transcription factor binding]
GO:0001047 [core promoter binding]
GO:0002076 [osteoblast development]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0010629 [negative regulation of gene expression]
GO:0010830 [regulation of myotube differentiation]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014823 [response to activity]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0016604 [nuclear body]
GO:0030182 [neuron differentiation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033555 [multicellular organismal response to stress]
GO:0033558 [protein deacetylase activity]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042113 [B cell activation]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042826 [histone deacetylase binding]
GO:0043234 [protein complex]
GO:0043393 [regulation of protein binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
Show all
 1123 aa
122 kDa 		No 0
HDAC5-007
ENSP00000465229
ENST00000588703
K7EJL6 [Direct mapping]
Histone deacetylase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.4 kDa 		No 0
HDAC5-008
ENSP00000465393
ENST00000587135
K7EJZ7 [Direct mapping]
Histone deacetylase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
4.2 kDa 		No 0
HDAC5-009
ENSP00000468485
ENST00000591714
K7ES01 [Direct mapping]
Histone deacetylase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.3 kDa 		No 0
HDAC5-010
ENSP00000465227
ENST00000588261
K7EJL4 [Direct mapping]
Histone deacetylase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0016575 [histone deacetylation]
GO:0040029 [regulation of gene expression, epigenetic]
Show all
 282 aa
29.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.