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Most cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Lymphomas and testicular cancers along with several gliomas, squamous cell carcinomas and urothelial cancers were negative.
A majority of cancer tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in most colorectal cancers and few cases of melanomas, pancreatic, liver and endometrial cancers. Several lymphomas were negative.
GENE INFORMATION
Gene name
ABCC3 (HGNC Symbol)
Synonyms
cMOAT2, EST90757, MLP2, MOAT-D, MRP3
Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
