Tissue expression of PRKAR1A - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PRKAR1A

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PRKAR1A
Gene description	Protein kinase, cAMP-dependent, regulatory, type I, alpha
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membrane and cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA049979 , CAB019378
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PRKAR1A (HGNC Symbol)
Synonyms	CNC1, PRKAR1, TSE1
Description	Protein kinase, cAMP-dependent, regulatory, type I, alpha (HGNC Symbol)
Entrez gene summary	cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	68511780 - 68551319
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108946 (version 83.38)
Entrez gene	5573
UniProt	P10644 (UniProt - Evidence at protein level)
neXtProt	NX_P10644
Antibodypedia	PRKAR1A antibodies

PROTEIN BROWSER

PRKAR1A-001	PRKAR1A-002	PRKAR1A-004	PRKAR1A-005	PRKAR1A-006	PRKAR1A-008	PRKAR1A-010	PRKAR1A-011	PRKAR1A-012	PRKAR1A-013	PRKAR1A-014	PRKAR1A-015	PRKAR1A-016	PRKAR1A-019	PRKAR1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKAR1A-001 ENSP00000464977 ENST00000589228	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	381 aa 43 kDa	No	0
PRKAR1A-002 ENSP00000445625 ENST00000536854	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	381 aa 43 kDa	No	0
PRKAR1A-004 ENSP00000351410 ENST00000358598	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	381 aa 43 kDa	No	0
PRKAR1A-005 ENSP00000466459 ENST00000586397	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	381 aa 43 kDa	No	0
PRKAR1A-006 ENSP00000468106 ENST00000588188	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	337 aa 38 kDa	No	0
PRKAR1A-008 ENSP00000465445 ENST00000589017	K7EK41 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		204 aa 22.9 kDa	No	0
PRKAR1A-010 ENSP00000464715 ENST00000585427	K7EIE5 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.9 kDa	No	0
PRKAR1A-011 ENSP00000464701 ENST00000588702	K7EID3 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		168 aa 19 kDa	No	0
PRKAR1A-012 ENSP00000467500 ENST00000589309	K7EPR5 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.2 kDa	No	0
PRKAR1A-013 ENSP00000467311 ENST00000585981	K7EPB2 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001932 [regulation of protein phosphorylation] GO:0005952 [cAMP-dependent protein kinase complex] GO:0008603 [cAMP-dependent protein kinase regulator activity] Show all	297 aa 33.6 kDa	No	0
PRKAR1A-014 ENSP00000466649 ENST00000589480	K7EMU2 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.9 kDa	No	0
PRKAR1A-015 ENSP00000467867 ENST00000585815	K7EQK3 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.6 kDa	No	0
PRKAR1A-016 ENSP00000465013 ENST00000588178	K7EJ40 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		182 aa 20.6 kDa	No	0
PRKAR1A-019 ENSP00000466314 ENST00000592800	K7EM13 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.3 kDa	No	0
PRKAR1A-201 ENSP00000376475 ENST00000392711	P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001707 [mesoderm formation] GO:0001772 [immunological synapse] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006469 [negative regulation of protein kinase activity] GO:0006833 [water transport] GO:0007143 [female meiotic division] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031594 [neuromuscular junction] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0044853 [plasma membrane raft] GO:0045087 [innate immune response] GO:0045214 [sarcomere organization] GO:0045835 [negative regulation of meiotic nuclear division] GO:0045859 [regulation of protein kinase activity] GO:0046007 [negative regulation of activated T cell proliferation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0060038 [cardiac muscle cell proliferation] GO:0071377 [cellular response to glucagon stimulus] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity] Show all	381 aa 43 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.