Tissue expression of DPH1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DPH1
Gene description	Diphthamide biosynthesis 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DPH1 (HGNC Symbol)
Synonyms	DPH2L, DPH2L1, OVCA1
Description	Diphthamide biosynthesis 1 (HGNC Symbol)
Entrez gene summary	Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2030110 - 2043430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108963 (version 83.38)
Entrez gene	1801
UniProt	Q9BZG8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZG8
Antibodypedia	DPH1 antibodies

PROTEIN BROWSER

DPH1-001	DPH1-003	DPH1-007	DPH1-009	DPH1-017	DPH1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPH1-001 ENSP00000263083 ENST00000263083	Q9BZG8 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008283 [cell proliferation] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	443 aa 48.8 kDa	No	0
DPH1-003 ENSP00000458726 ENST00000570477	Q9BZG8 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	363 aa 40 kDa	No	0
DPH1-007 ENSP00000458838 ENST00000571418	I3L1H5 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] Show all	431 aa 47.3 kDa	No	0
DPH1-009 ENSP00000460813 ENST00000571710	I3L3X9 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] Show all	148 aa 16.2 kDa	No	0
DPH1-017 ENSP00000476598 ENST00000575162	V9GYC0 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] Show all	107 aa 11.4 kDa	No	0
DPH1-018 ENSP00000476070 ENST00000607788	U3KQN3 [Direct mapping] Diphthamide biosynthesis protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] Show all	103 aa 11.2 kDa	No	0