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IFT20

CANCER ATLAS

Gene description

 Intraflagellar transport 20

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021376

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most cancers showed moderate to strong cytoplasmic immunoreactivity, in some cases combined with membranous staining. Hepatocellular carcinomas as well as a few prostate, renal and stomach cancers were negative.

GENE INFORMATION

Gene name

 IFT20

Synonyms

Description

 Intraflagellar transport 20 (HGNC Symbol)

Entrez gene summary

 This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28328325 - 28335489

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109083 (version 83.38)

Entrez gene

 90410

UniProt

 Q8IY31 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IY31

Antibodypedia

 IFT20 antibodies

PROTEIN BROWSER
IFT20-001
IFT20-002
IFT20-008
IFT20-009
IFT20-012
IFT20-014
IFT20-015
IFT20-016
IFT20-017
IFT20-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFT20-001
ENSP00000464443
ENST00000585089
Q8IY31 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001750 [photoreceptor outer segment]
GO:0001822 [kidney development]
GO:0002046 [opsin binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0007224 [smoothened signaling pathway]
GO:0008542 [visual learning]
GO:0015630 [microtubule cytoskeleton]
GO:0022008 [neurogenesis]
GO:0030992 [intraciliary transport particle B]
GO:0031514 [motile cilium]
GO:0032391 [photoreceptor connecting cilium]
GO:0034067 [protein localization to Golgi apparatus]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0036372 [opsin transport]
GO:0042384 [cilium assembly]
GO:0044292 [dendrite terminus]
GO:0051642 [centrosome localization]
GO:0055007 [cardiac muscle cell differentiation]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061351 [neural precursor cell proliferation]
GO:0061512 [protein localization to cilium]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
GO:1902017 [regulation of cilium assembly]
GO:2000785 [regulation of autophagosome assembly]
Show all
 158 aa
18.1 kDa 		No 0
IFT20-002
ENSP00000350570
ENST00000357896
Q8IY31 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030992 [intraciliary transport particle B]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042384 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2000785 [regulation of autophagosome assembly]
Show all
 148 aa
16 kDa 		No 0
IFT20-008
ENSP00000463138
ENST00000585313
Q8IY31 [Direct mapping]
Intraflagellar transport protein 20 homolog
A0A024QZ08 [Target identity:100%; Query identity:100%]
Intraflagellar transport 20 homolog (Chlamydomonas), isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030992 [intraciliary transport particle B]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042384 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2000785 [regulation of autophagosome assembly]
Show all
 132 aa
15.3 kDa 		No 0
IFT20-009
ENSP00000462163
ENST00000577498
J3KRU2 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015630 [microtubule cytoskeleton]
Show all
 85 aa
9.5 kDa 		No 0
IFT20-012
ENSP00000464033
ENST00000578985
J3QR43 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015630 [microtubule cytoskeleton]
Show all
 132 aa
14.9 kDa 		No 0
IFT20-014
ENSP00000464147
ENST00000578122
J3QRC6 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015630 [microtubule cytoskeleton]
Show all
 141 aa
15.9 kDa 		No 0
IFT20-015
ENSP00000378809
ENST00000395418
Q8IY31 [Direct mapping]
Intraflagellar transport protein 20 homolog
A0A024QZ08 [Target identity:100%; Query identity:100%]
Intraflagellar transport 20 homolog (Chlamydomonas), isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030992 [intraciliary transport particle B]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042384 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2000785 [regulation of autophagosome assembly]
Show all
 132 aa
15.3 kDa 		No 0
IFT20-016
ENSP00000463322
ENST00000579419
Q8IY31 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0006996 [organelle organization]
GO:0015630 [microtubule cytoskeleton]
GO:0030992 [intraciliary transport particle B]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042384 [cilium assembly]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
GO:2000785 [regulation of autophagosome assembly]
Show all
 114 aa
13 kDa 		No 0
IFT20-017
ENSP00000464210
ENST00000578009
J3QRH2 [Direct mapping]
Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
8 kDa 		No 0
IFT20-201
ENSP00000484842
ENST00000588477
A0A087X2B4 [Direct mapping]
Intraflagellar transport 20 homolog (Chlamydomonas), isoform CRA_b; Intraflagellar transport protein 20 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031514 [motile cilium]
Show all
 74 aa
8.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.