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FOXN1

GENERAL INFORMATION

Gene name

 FOXN1

Gene description

 Forkhead box N1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin, esophagus)
GTEx:Group enriched (skin, esophagus, vagina)
FANTOM5:Group enriched (tonsil, esophagus, cervix, uterine)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skin, esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, esophagus, cervix, uterine)

GENE INFORMATION

Gene name

 FOXN1 (HGNC Symbol)

Synonyms

 FKHL20, RONU, WHN

Description

 Forkhead box N1 (HGNC Symbol)

Entrez gene summary

 Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28506243 - 28538896

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000109101 (version 83.38)

Entrez gene

 8456

UniProt

 O15353 (UniProt - Evidence at transcript level)

neXtProt

 NX_O15353

Antibodypedia

 FOXN1 antibodies

PROTEIN BROWSER
FOXN1-001
FOXN1-002
FOXN1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXN1-001
ENSP00000226247
ENST00000226247
O15353 [Direct mapping]
Forkhead box protein N1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001942 [hair follicle development]
GO:0002260 [lymphocyte homeostasis]
GO:0002360 [T cell lineage commitment]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006952 [defense response]
GO:0008283 [cell proliferation]
GO:0008544 [epidermis development]
GO:0009887 [organ morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0033081 [regulation of T cell differentiation in thymus]
GO:0035878 [nail development]
GO:0043029 [T cell homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0048514 [blood vessel morphogenesis]
GO:0048538 [thymus development]
GO:0050673 [epithelial cell proliferation]
GO:0051798 [positive regulation of hair follicle development]
GO:0097535 [lymphoid lineage cell migration into thymus]
GO:0097536 [thymus epithelium morphogenesis]
GO:1902232 [regulation of positive thymic T cell selection]
Show all
 648 aa
68.9 kDa 		No 0
FOXN1-002
ENSP00000464645
ENST00000579795
O15353 [Direct mapping]
Forkhead box protein N1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006952 [defense response]
GO:0008544 [epidermis development]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 648 aa
68.9 kDa 		No 0
FOXN1-003
ENSP00000462159
ENST00000577936
J3KRT9 [Direct mapping]
Forkhead box protein N1
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
Show all
 117 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.