Cell atlas - ALDOC - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ALDOC
Gene description	Aldolase C, fructose-bisphosphate
Protein class	Cancer-related genes Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cytosol & vesicles.
RNA cell category	Cell line enhanced (RPMI-8226, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli fibrillar center (approved)
Additional location	In addition localized to the Vesicles (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003282
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to the cytosol & vesicles.

Main location

Nucleus (approved), Nucleoli fibrillar center (approved)

Additional location

Vesicles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA003282	A-431	Nucleus	Intensity
		Nucleoli fibrillar center
		Cytosol
HPA003282	U-2 OS	Nucleoli fibrillar center
		Vesicles
		Cytosol
HPA003282	U-251 MG	Nucleus
		Nucleoli fibrillar center
		Cytosol

GENE INFORMATION
Gene name	ALDOC
Synonyms
Description	Aldolase C, fructose-bisphosphate (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28573115 - 28577264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109107 (version 83.38)
Entrez gene	230
UniProt	P09972 (UniProt - Evidence at protein level)
neXtProt	NX_P09972
Antibodypedia	ALDOC antibodies

PROTEIN BROWSER

ALDOC-001	ALDOC-002	ALDOC-003	ALDOC-004	ALDOC-005	ALDOC-006	ALDOC-007	ALDOC-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDOC-001 ENSP00000226253 ENST00000226253	P09972 [Direct mapping] Fructose-bisphosphate aldolase C A0A024QZ64 [Target identity:100%; Query identity:100%] Fructose-bisphosphate aldolase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008092 [cytoskeletal protein binding] GO:0030388 [fructose 1,6-bisphosphate metabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	364 aa 39.5 kDa	No	0
ALDOC-002 ENSP00000378729 ENST00000395319	A8MVZ9 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	336 aa 36.3 kDa	No	0
ALDOC-003 ENSP00000378731 ENST00000395321	P09972 [Direct mapping] Fructose-bisphosphate aldolase C A0A024QZ64 [Target identity:100%; Query identity:100%] Fructose-bisphosphate aldolase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0008092 [cytoskeletal protein binding] GO:0030388 [fructose 1,6-bisphosphate metabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	364 aa 39.5 kDa	No	0
ALDOC-004 ENSP00000398976 ENST00000435638	C9J8F3 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	149 aa 16.3 kDa	No	0
ALDOC-005 ENSP00000463174 ENST00000460201	J3QKP5 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	180 aa 19.7 kDa	No	0
ALDOC-006 ENSP00000462674 ENST00000584086	J3KSV6 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	175 aa 19.1 kDa	No	0
ALDOC-007 ENSP00000463118 ENST00000578590	J3QKK1 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	122 aa 13.3 kDa	No	0
ALDOC-008 ENSP00000465623 ENST00000581807	K7EKH5 [Direct mapping] Fructose-bisphosphate aldolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004332 [fructose-bisphosphate aldolase activity] GO:0006096 [glycolytic process] Show all	135 aa 15 kDa	No	0