Cell atlas - CPE - The Human Protein Atlas

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CPE

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm
	Vesicles

Human cell
	Centrosome
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	CPE
Gene description	Carboxypeptidase E
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the nucleoplasm & vesicles.
RNA cell category	Group enriched (SiHa, SCLC-21H, Hep G2, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003819
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SiHa, SCLC-21H, Hep G2, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the nucleoplasm & vesicles.

Main location

Centrosome (approved)

Additional location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003819	A-431	Nucleoplasm
			Vesicles
			Centrosome
	HPA003819	U-2 OS	Centrosome
	HPA003819	U-251 MG	Vesicles
	HPA003819	U-251 MG	Centrosome

GENE INFORMATION
Gene name	CPE
Synonyms
Description	Carboxypeptidase E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Chromosome	4
Cytoband	q32.3
Chromosome location (bp)	165361194 - 165498320
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109472 (version 83.38)
Entrez gene	1363
UniProt	P16870 (UniProt - Evidence at protein level)
neXtProt	NX_P16870
Antibodypedia	CPE antibodies

PROTEIN BROWSER

CPE-001	CPE-002	CPE-006	CPE-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPE-001 ENSP00000386104 ENST00000402744	P16870 [Direct mapping] Carboxypeptidase E Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003214 [cardiac left ventricle morphogenesis] GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006464 [cellular protein modification process] GO:0006508 [proteolysis] GO:0007218 [neuropeptide signaling pathway] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0030070 [insulin processing] GO:0030658 [transport vesicle membrane] GO:0030667 [secretory granule membrane] GO:0042043 [neurexin family protein binding] GO:0044267 [cellular protein metabolic process] GO:0050839 [cell adhesion molecule binding] GO:0070062 [extracellular exosome] GO:0072657 [protein localization to membrane] Show all	476 aa 53.2 kDa	Yes	0
CPE-002 ENSP00000416601 ENST00000431967	C9JE88 [Direct mapping] Carboxypeptidase E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	147 aa 16.6 kDa	No	0
CPE-006 ENSP00000424830 ENST00000513982	D6RF88 [Direct mapping] Carboxypeptidase E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	139 aa 15.7 kDa	No	0
CPE-007 ENSP00000423699 ENST00000511992	D6R930 [Direct mapping] Carboxypeptidase E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	157 aa 17.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.