Cell atlas - CLNK - The Human Protein Atlas

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CLNK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CLNK
Gene description	Cytokine-dependent hematopoietic cell linker
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles.
RNA cell category	Group enriched (HDLM-2, U-937)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA035671
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HDLM-2, U-937) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035671	A-431	Vesicles
	HPA035671	U-2 OS	Nucleoplasm
	HPA035671	U-2 OS	Vesicles
	HPA035671	U-251 MG	Nucleoplasm
	HPA035671	U-251 MG	Vesicles

GENE INFORMATION
Gene name	CLNK (HGNC Symbol)
Synonyms	MIST
Description	Cytokine-dependent hematopoietic cell linker (HGNC Symbol)
Entrez gene summary	MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	10486395 - 10684865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109684 (version 83.38)
Entrez gene	116449
UniProt	Q7Z7G1 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7G1
Antibodypedia	CLNK antibodies

PROTEIN BROWSER

CLNK-001	CLNK-002	CLNK-003	CLNK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLNK-001 ENSP00000226951 ENST00000226951	Q7Z7G1 [Direct mapping] Cytokine-dependent hematopoietic cell linker Show all	Predicted intracellular proteins Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0035556 [intracellular signal transduction] Show all	428 aa 49.6 kDa	No	0
CLNK-002 ENSP00000427208 ENST00000507719	Q7Z7G1 [Direct mapping] Cytokine-dependent hematopoietic cell linker Show all	Predicted intracellular proteins Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0035556 [intracellular signal transduction] Show all	169 aa 19.4 kDa	No	0
CLNK-003 ENSP00000427256 ENST00000515667	D6RJB9 [Direct mapping] Cytokine-dependent hematopoietic cell linker Show all	Predicted intracellular proteins Show all	GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] Show all	166 aa 19.5 kDa	No	0
CLNK-201 ENSP00000390744 ENST00000442825	A0A0A0MSJ4 [Direct mapping] Cytokine-dependent hematopoietic cell linker Show all	Predicted intracellular proteins Show all	GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] Show all	428 aa 49.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.