Cell atlas - STIM2 - The Human Protein Atlas

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STIM2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	STIM2
Gene description	Stromal interaction molecule 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036933
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036933	A-431	Vesicles
	HPA036933	U-2 OS	Vesicles
	HPA036933	U-251 MG	Vesicles

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000039156 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA036933	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	STIM2
Synonyms
Description	Stromal interaction molecule 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	26857678 - 27025381
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109689 (version 83.38)
Entrez gene	57620
UniProt	Q9P246 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P246
Antibodypedia	STIM2 antibodies

PROTEIN BROWSER

STIM2-001	STIM2-002	STIM2-003	STIM2-004	STIM2-005	STIM2-006	STIM2-007	STIM2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STIM2-001 ENSP00000419073 ENST00000467087	Q9P246 [Direct mapping] Stromal interaction molecule 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006874 [cellular calcium ion homeostasis] GO:0015279 [store-operated calcium channel activity] GO:0016021 [integral component of membrane] GO:0032237 [activation of store-operated calcium channel activity] GO:0051928 [positive regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	746 aa 84 kDa	Yes	1
STIM2-002 ENSP00000417569 ENST00000465503	H0Y860 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0032237 [activation of store-operated calcium channel activity] Show all	754 aa 84.8 kDa	Yes	1
STIM2-003 ENSP00000419383 ENST00000467011	H7C5A5 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	599 aa 68 kDa	Yes	1
STIM2-004 ENSP00000420113 ENST00000473519	H7C5K2 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		347 aa 39.6 kDa	No	0
STIM2-005 ENSP00000419536 ENST00000477474	H7C5C6 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 24.5 kDa	No	0
STIM2-006 ENSP00000473581 ENST00000478049	R4GNC5 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 10.5 kDa	No	0
STIM2-007 ENSP00000473283 ENST00000463501	R4GMP0 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	214 aa 25.2 kDa	No	1
STIM2-008 ENSP00000473527 ENST00000494628	R4GN82 [Direct mapping] Stromal interaction molecule 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	159 aa 18.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.