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NKX3-2

GENERAL INFORMATION

Gene name

 NKX3-2

Gene description

 NK3 homeobox 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Tissue enriched (colon)
FANTOM5:Group enriched (colon, appendix)

Protein evidence

 Evidence at transcript level

Protein expression

 Nuclear expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA027564
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, appendix)

GENE INFORMATION

Gene name

 NKX3-2 (HGNC Symbol)

Synonyms

 BAPX1, NKX3.2, NKX3B

Description

 NK3 homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p15.33

Chromosome location (bp)

 13540830 - 13545050

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000109705 (version 83.38)

Entrez gene

 579

UniProt

 P78367 (UniProt - Evidence at transcript level)

neXtProt

 NX_P78367

Antibodypedia

 NKX3-2 antibodies

PROTEIN BROWSER
NKX3-2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX3-2-001
ENSP00000371875
ENST00000382438
P78367 [Direct mapping]
Homeobox protein Nkx-3.2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007368 [determination of left/right symmetry]
GO:0031016 [pancreas development]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0042474 [middle ear morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0048513 [organ development]
GO:0048536 [spleen development]
GO:0048645 [organ formation]
GO:0048705 [skeletal system morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0055123 [digestive system development]
GO:0060576 [intestinal epithelial cell development]
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 333 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.