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GLRB

GENERAL INFORMATION

Gene name

 GLRB

Gene description

 Glycine receptor, beta

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, parathyroid gland)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Group enriched (caudate, hippocampus, brain, cerebellum, pituitary gland, salivary gland, pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in neuronal processes of CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA052363
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus, brain, cerebellum, pituitary gland, salivary gland, pancreas)

GENE INFORMATION

Gene name

 GLRB

Synonyms

Description

 Glycine receptor, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 157076057 - 157172090

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109738 (version 83.38)

Entrez gene

 2743

UniProt

 P48167 (UniProt - Evidence at protein level)

neXtProt

 NX_P48167

Antibodypedia

 GLRB antibodies

PROTEIN BROWSER
GLRB-001
GLRB-002
GLRB-005
GLRB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRB-001
ENSP00000264428
ENST00000264428
P48167 [Direct mapping]
Glycine receptor subunit beta
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001964 [startle response]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007340 [acrosome reaction]
GO:0007399 [nervous system development]
GO:0007601 [visual perception]
GO:0007628 [adult walking behavior]
GO:0008144 [drug binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016933 [extracellular-glycine-gated ion channel activity]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050905 [neuromuscular process]
GO:0051291 [protein heterooligomerization]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:0060013 [righting reflex]
GO:0072578 [neurotransmitter-gated ion channel clustering]
GO:0097112 [gamma-aminobutyric acid receptor clustering]
GO:1902476 [chloride transmembrane transport]
Show all
 497 aa
56.1 kDa 		Yes 4
GLRB-002
ENSP00000427186
ENST00000509282
P48167 [Direct mapping]
Glycine receptor subunit beta
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001964 [startle response]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016933 [extracellular-glycine-gated ion channel activity]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 497 aa
56.1 kDa 		Yes 4
GLRB-005
ENSP00000425433
ENST00000512619
D6RD86 [Direct mapping]
Glycine receptor subunit beta
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 56 aa
6.4 kDa 		Yes 0
GLRB-201
ENSP00000441873
ENST00000541722
P48167 [Direct mapping]
Glycine receptor subunit beta
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001964 [startle response]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016933 [extracellular-glycine-gated ion channel activity]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 303 aa
34.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.