Expression of BST1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Bone marrow stromal cell antigen 1

Protein class

CD markers, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050121

GENE INFORMATION
Gene name	BST1 (HGNC Symbol)
Synonyms	CD157
Description	Bone marrow stromal cell antigen 1 (HGNC Symbol)
Entrez gene summary	Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p15.32
Chromosome location (bp)	15702950 - 15738313
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109743 (version 83.38)
Entrez gene	683
UniProt	Q10588 (UniProt - Evidence at protein level)
neXtProt	NX_Q10588
Antibodypedia	BST1 antibodies

PROTEIN BROWSER

BST1-001	BST1-002	BST1-003	BST1-004	BST1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BST1-001 ENSP00000265016 ENST00000265016	Q10588 [Direct mapping] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Show all	Enzymes ENZYME proteins Hydrolases CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003953 [NAD+ nucleosidase activity] GO:0005886 [plasma membrane] GO:0006959 [humoral immune response] GO:0007275 [multicellular organismal development] GO:0008152 [metabolic process] GO:0016740 [transferase activity] GO:0016849 [phosphorus-oxygen lyase activity] GO:0019898 [extrinsic component of membrane] GO:0030890 [positive regulation of B cell proliferation] GO:0031225 [anchored component of membrane] GO:0050135 [NAD(P)+ nucleosidase activity] GO:0070062 [extracellular exosome] Show all	318 aa 35.7 kDa	Yes	0
BST1-002 ENSP00000371783 ENST00000382346	A6NC48 [Direct mapping] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003953 [NAD+ nucleosidase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0030890 [positive regulation of B cell proliferation] Show all	333 aa 37.5 kDa	Yes	0
BST1-003 ENSP00000424761 ENST00000514989	H0Y9Q9 [Direct mapping] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003953 [NAD+ nucleosidase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0030890 [positive regulation of B cell proliferation] Show all	97 aa 11 kDa	No	0
BST1-004 ENSP00000423357 ENST00000505785	H0Y984 [Direct mapping] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003953 [NAD+ nucleosidase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0030890 [positive regulation of B cell proliferation] Show all	186 aa 21 kDa	No	0
BST1-005 ENSP00000420925 ENST00000514445	H0Y8G4 [Direct mapping] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003953 [NAD+ nucleosidase activity] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0030890 [positive regulation of B cell proliferation] Show all	155 aa 17.6 kDa	No	0