Expression of HGFAC in cancer - Summary

CANCER ATLAS

Gene description

HGF activator

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA058279	HPA059076

GENE INFORMATION
Gene name	HGFAC (HGNC Symbol)
Synonyms	HGFA, HGFAP
Description	HGF activator (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	3441887 - 3449495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109758 (version 83.38)
Entrez gene	3083
UniProt	Q04756 (UniProt - Evidence at protein level)
neXtProt	NX_Q04756
Antibodypedia	HGFAC antibodies

PROTEIN BROWSER

HGFAC-001	HGFAC-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HGFAC-001 ENSP00000372224 ENST00000382774	Q04756 [Direct mapping] Hepatocyte growth factor activator Hepatocyte growth factor activator short chain Hepatocyte growth factor activator long chain Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	655 aa 70.7 kDa	Yes	0
HGFAC-004 ENSP00000421801 ENST00000511533	D6RAR4 [Direct mapping] Hepatocyte growth factor activator Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005791 [rough endoplasmic reticulum] GO:0006508 [proteolysis] Show all	662 aa 71.5 kDa	Yes	0