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Most cancer tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in a few cases of lymphomas and hepatocellular carcinomas. Most skin and cervical cancers were negative.
Cancer cells displayed weak to moderate nuclear staining with additional cytoplasmic positivity in several cases. Papillary adenocarcinomas of thyroid and a few cases of colorectal, lung and skin cancers were strongly stained. Several cases of cervical, endometrial, renal and prostate cancers were negative.
GENE INFORMATION
Gene name
UFSP2 (HGNC Symbol)
Synonyms
C4orf20, FLJ11200
Description
UFM1-specific peptidase 2 (HGNC Symbol)
Entrez gene summary
Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009]
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
