Expression of CRTAM in cancer - Summary

CANCER ATLAS

Gene description

Cytotoxic and regulatory T cell molecule

Protein class

CD markers, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054595

GENE INFORMATION
Gene name	CRTAM (HGNC Symbol)
Synonyms	CD355
Description	Cytotoxic and regulatory T cell molecule (HGNC Symbol)
Entrez gene summary	The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Chromosome	11
Cytoband	q24.1
Chromosome location (bp)	122838500 - 122872639
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109943 (version 83.38)
Entrez gene	56253
UniProt	O95727 (UniProt - Evidence at protein level)
neXtProt	NX_O95727
Antibodypedia	CRTAM antibodies

PROTEIN BROWSER

CRTAM-001	CRTAM-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRTAM-001 ENSP00000227348 ENST00000227348	O95727 [Direct mapping] Cytotoxic and regulatory T-cell molecule Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002355 [detection of tumor cell] GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0042803 [protein homodimerization activity] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] Show all	393 aa 44.6 kDa	Yes	1
CRTAM-002 ENSP00000433728 ENST00000533709	O95727 [Direct mapping] Cytotoxic and regulatory T-cell molecule Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002355 [detection of tumor cell] GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0008037 [cell recognition] GO:0042803 [protein homodimerization activity] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050715 [positive regulation of cytokine secretion] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0051606 [detection of stimulus] Show all	194 aa 22.3 kDa	Yes	1