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HSPA8

CANCER ATLAS

Gene description

 Heat shock 70kDa protein 8

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA052504
CAB002056

GENE INFORMATION

Gene name

 HSPA8 (HGNC Symbol)

Synonyms

 HSC70, HSC71, HSP73, HSPA10

Description

 Heat shock 70kDa protein 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q24.1

Chromosome location (bp)

 123057489 - 123063230

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109971 (version 83.38)

Entrez gene

 3312

UniProt

 P11142 (UniProt - Evidence at protein level)

neXtProt

 NX_P11142

Antibodypedia

 HSPA8 antibodies

PROTEIN BROWSER
«
HSPA8-001
HSPA8-002
HSPA8-003
HSPA8-004
HSPA8-006
HSPA8-009
HSPA8-010
HSPA8-011
HSPA8-012
HSPA8-015
HSPA8-018
HSPA8-021
HSPA8-022
HSPA8-023
HSPA8-024
HSPA8-027
HSPA8-028
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSPA8-001
ENSP00000432083
ENST00000534624
P11142 [Direct mapping]
Heat shock cognate 71 kDa protein
V9HW22 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 33; Epididymis secretory sperm binding protein Li 72p; Heat shock 70kDa protein 8, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001664 [G-protein coupled receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0006622 [protein targeting to lysosome]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006986 [response to unfolded protein]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007411 [axon guidance]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030529 [ribonucleoprotein complex]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034605 [cellular response to heat]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042623 [ATPase activity, coupled]
GO:0043202 [lysosomal lumen]
GO:0043209 [myelin sheath]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046034 [ATP metabolic process]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
GO:0051082 [unfolded protein binding]
GO:0051085 [chaperone mediated protein folding requiring cofactor]
GO:0051726 [regulation of cell cycle]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0061024 [membrane organization]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0072318 [clathrin coat disassembly]
GO:0072562 [blood microparticle]
GO:1900034 [regulation of cellular response to heat]
GO:1902904 [negative regulation of fibril organization]
Show all
 646 aa
70.9 kDa 		No 0
HSPA8-002
ENSP00000404372
ENST00000453788
P11142 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001664 [G-protein coupled receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0006622 [protein targeting to lysosome]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006986 [response to unfolded protein]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007411 [axon guidance]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030529 [ribonucleoprotein complex]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034605 [cellular response to heat]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042623 [ATPase activity, coupled]
GO:0043202 [lysosomal lumen]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046034 [ATP metabolic process]
GO:0051082 [unfolded protein binding]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0061024 [membrane organization]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1900034 [regulation of cellular response to heat]
GO:1902904 [negative regulation of fibril organization]
Show all
 493 aa
53.5 kDa 		No 0
HSPA8-003
ENSP00000437189
ENST00000533540
E9PNE6 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 500 aa
55 kDa 		No 0
HSPA8-004
ENSP00000437125
ENST00000532636
P11142 [Direct mapping]
Heat shock cognate 71 kDa protein
V9HW22 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 33; Epididymis secretory sperm binding protein Li 72p; Heat shock 70kDa protein 8, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001664 [G-protein coupled receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0006622 [protein targeting to lysosome]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006986 [response to unfolded protein]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007411 [axon guidance]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030529 [ribonucleoprotein complex]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034605 [cellular response to heat]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042623 [ATPase activity, coupled]
GO:0043202 [lysosomal lumen]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046034 [ATP metabolic process]
GO:0051082 [unfolded protein binding]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0061024 [membrane organization]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1900034 [regulation of cellular response to heat]
GO:1902904 [negative regulation of fibril organization]
Show all
 646 aa
70.9 kDa 		No 0
HSPA8-006
ENSP00000227378
ENST00000227378
P11142 [Direct mapping]
Heat shock cognate 71 kDa protein
V9HW22 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 33; Epididymis secretory sperm binding protein Li 72p; Heat shock 70kDa protein 8, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001664 [G-protein coupled receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006457 [protein folding]
GO:0006622 [protein targeting to lysosome]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006986 [response to unfolded protein]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007411 [axon guidance]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019899 [enzyme binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030529 [ribonucleoprotein complex]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034605 [cellular response to heat]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042623 [ATPase activity, coupled]
GO:0043202 [lysosomal lumen]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046034 [ATP metabolic process]
GO:0051082 [unfolded protein binding]
GO:0055131 [C3HC4-type RING finger domain binding]
GO:0061024 [membrane organization]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1900034 [regulation of cellular response to heat]
GO:1902904 [negative regulation of fibril organization]
Show all
 646 aa
70.9 kDa 		No 0
HSPA8-009
ENSP00000433584
ENST00000526110
E9PKE3 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 627 aa
68.8 kDa 		No 0
HSPA8-010
ENSP00000433316
ENST00000534319
A8K7Q2 [Direct mapping]
Heat shock cognate 71 kDa protein; cDNA FLJ77848
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 410 aa
45.3 kDa 		No 0
HSPA8-011
ENSP00000435154
ENST00000525624
E9PLF4 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 187 aa
20.4 kDa 		No 0
HSPA8-012
ENSP00000436183
ENST00000527387
E9PQK7 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 178 aa
19.5 kDa 		No 0
HSPA8-015
ENSP00000432884
ENST00000528292
E9PN89 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 312 aa
34.8 kDa 		No 0
HSPA8-018
ENSP00000436762
ENST00000525463
E9PI65 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 168 aa
17.9 kDa 		No 0
HSPA8-021
ENSP00000434415
ENST00000532182
E9PQQ4 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 171 aa
18.7 kDa 		No 0
HSPA8-022
ENSP00000434851
ENST00000530391
E9PN25 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 132 aa
14.6 kDa 		No 0
HSPA8-023
ENSP00000431641
ENST00000534567
E9PK54 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 184 aa
20 kDa 		No 0
HSPA8-024
ENSP00000434565
ENST00000524590
E9PPY6 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 137 aa
15.2 kDa 		No 0
HSPA8-027
ENSP00000435908
ENST00000524552
E9PS65 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 223 aa
24.9 kDa 		No 0
HSPA8-028
ENSP00000435019
ENST00000526686
E9PM13 [Direct mapping]
Heat shock cognate 71 kDa protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 151 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.