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SNX15

CANCER ATLAS

Gene description

 Sorting nexin 15

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038955

GENE INFORMATION

Gene name

 SNX15

Synonyms

Description

 Sorting nexin 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65027408 - 65040572

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110025 (version 83.38)

Entrez gene

 29907

UniProt

 Q9NRS6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRS6

Antibodypedia

 SNX15 antibodies

PROTEIN BROWSER
SNX15-001
SNX15-002
SNX15-004
SNX15-006
SNX15-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX15-001
ENSP00000366452
ENST00000377244
Q9NRS6 [Direct mapping]
Sorting nexin-15
E5KQS5 [Target identity:100%; Query identity:100%]
HCG2044837; Sorting nexin-15
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0016020 [membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 342 aa
38.3 kDa 		No 0
SNX15-002
ENSP00000316410
ENST00000352068
Q9NRS6 [Direct mapping]
Sorting nexin-15
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0016020 [membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 256 aa
29.2 kDa 		No 0
SNX15-004
ENSP00000437277
ENST00000534637
E9PMW6 [Direct mapping]
Sorting nexin-15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 217 aa
24.9 kDa 		No 0
SNX15-006
ENSP00000431690
ENST00000524831
E9PK26 [Direct mapping]
Sorting nexin-15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 192 aa
22 kDa 		No 0
SNX15-007
ENSP00000436023
ENST00000525648
E9PR81 [Direct mapping]
Sorting nexin-15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 66 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.