Cell atlas - SUV420H1 - The Human Protein Atlas

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SUV420H1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SUV420H1
Gene description	Suppressor of variegation 4-20 homolog 1 (Drosophila)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA063648
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063648	CACO-2	Nucleus
	HPA063648	SK-MEL-30	Nucleus
	HPA063648	U-2 OS	Nucleus

GENE INFORMATION
Gene name	SUV420H1 (HGNC Symbol)
Synonyms	CGI-85, KMT5B
Description	Suppressor of variegation 4-20 homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	68154863 - 68213828
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110066 (version 83.38)
Entrez gene	51111
UniProt	Q4FZB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q4FZB7
Antibodypedia	SUV420H1 antibodies

PROTEIN BROWSER

SUV420H1-001	SUV420H1-003	SUV420H1-004	SUV420H1-005	SUV420H1-006	SUV420H1-008	SUV420H1-009	SUV420H1-010	SUV420H1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUV420H1-001 ENSP00000305899 ENST00000304363	Q4FZB7 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000780 [condensed nuclear chromosome, centromeric region] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	885 aa 99.2 kDa	No	0
SUV420H1-003 ENSP00000385640 ENST00000405515	Q4FZB7 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	393 aa 44.6 kDa	No	0
SUV420H1-004 ENSP00000403233 ENST00000458496	C9JFG1 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Predicted intracellular proteins Show all		100 aa 11.7 kDa	No	0
SUV420H1-005 ENSP00000384724 ENST00000402185	B7WNX0 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	370 aa 42.1 kDa	No	0
SUV420H1-006 ENSP00000406377 ENST00000453170	C9J6S5 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Predicted intracellular proteins Show all		120 aa 14.3 kDa	No	0
SUV420H1-008 ENSP00000402921 ENST00000434573	C9JP58 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Predicted intracellular proteins Show all		118 aa 13.1 kDa	No	0
SUV420H1-009 ENSP00000385005 ENST00000402789	B5MCB3 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	402 aa 45.7 kDa	No	0
SUV420H1-010 ENSP00000385965 ENST00000401547	Q4FZB7 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	393 aa 44.6 kDa	No	0
SUV420H1-201 ENSP00000484858 ENST00000615954	Q4FZB7 [Direct mapping] Histone-lysine N-methyltransferase SUV420H1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034773 [histone H4-K20 trimethylation] GO:0042799 [histone methyltransferase activity (H4-K20 specific)] Show all	885 aa 99.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.