Cell atlas - NRXN2 - The Human Protein Atlas

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NRXN2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane
	Nucleus

Human cell
	Cytosol
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NRXN2
Gene description	Neurexin 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (REH, U-2 OS, SCLC-21H, U-87 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051470
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, U-2 OS, SCLC-21H, U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the nucleus & cytosol.

Main location

Nuclear membrane (approved)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051470	SH-SY5Y	Nucleus
			Nuclear membrane
			Cytosol

GENE INFORMATION
Gene name	NRXN2
Synonyms
Description	Neurexin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64606174 - 64723188
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110076 (version 83.38)
Entrez gene	9379
UniProt	P58401 (UniProt - Evidence at protein level), Q9P2S2 (UniProt - Evidence at transcript level)
neXtProt	NX_P58401, NX_Q9P2S2
Antibodypedia	NRXN2 antibodies

PROTEIN BROWSER

NRXN2-001	NRXN2-002	NRXN2-003	NRXN2-006	NRXN2-011	NRXN2-012	NRXN2-013	NRXN2-015	NRXN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRXN2-001 ENSP00000366774 ENST00000377551	Q9P2S2 [Direct mapping] Neurexin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005623 [cell] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030534 [adult behavior] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0046872 [metal ion binding] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering involved in postsynaptic density assembly] GO:0097118 [neuroligin clustering involved in postsynaptic membrane assembly] GO:0097119 [postsynaptic density protein 95 clustering] Show all	1712 aa 185 kDa	Yes	1
NRXN2-002 ENSP00000366782 ENST00000377559	Q9P2S2 [Direct mapping] Neurexin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005623 [cell] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030534 [adult behavior] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0046872 [metal ion binding] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering involved in postsynaptic density assembly] GO:0097118 [neuroligin clustering involved in postsynaptic membrane assembly] GO:0097119 [postsynaptic density protein 95 clustering] Show all	1642 aa 177.3 kDa	Yes	1
NRXN2-003 ENSP00000301894 ENST00000301894	P58401 [Direct mapping] Neurexin-2-beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] GO:0050839 [cell adhesion molecule binding] GO:0097109 [neuroligin family protein binding] Show all	666 aa 70.9 kDa	Yes	1
NRXN2-006 ENSP00000407374 ENST00000423049	H7C2R8 [Direct mapping] Neurexin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	276 aa 29.7 kDa	Yes	0
NRXN2-011 ENSP00000388971 ENST00000442300	H7BZC7 [Direct mapping] Neurexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042734 [presynaptic membrane] Show all	293 aa 31.9 kDa	No	0
NRXN2-012 ENSP00000411271 ENST00000417749	H7C3D6 [Direct mapping] Neurexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042734 [presynaptic membrane] Show all	206 aa 22.2 kDa	No	0
NRXN2-013 ENSP00000412211 ENST00000437746	H7C3J4 [Direct mapping] Neurexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0042734 [presynaptic membrane] Show all	215 aa 22.8 kDa	No	0
NRXN2-015 ENSP00000386416 ENST00000409571	G5E9G7 [Direct mapping] Neurexin 2, isoform CRA_a; Neurexin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	1705 aa 184.1 kDa	Yes	1
NRXN2-201 ENSP00000265459 ENST00000265459	Q9P2S2 [Direct mapping] Neurexin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005623 [cell] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030534 [adult behavior] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0043234 [protein complex] GO:0046872 [metal ion binding] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering involved in postsynaptic density assembly] GO:0097118 [neuroligin clustering involved in postsynaptic membrane assembly] GO:0097119 [postsynaptic density protein 95 clustering] Show all	1712 aa 185 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.