Tissue expression of CPT1A - Summary - The Human Protein Atlas

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CPT1A

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CPT1A
Gene description	Carnitine palmitoyltransferase 1A (liver)
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA008835
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CPT1A (HGNC Symbol)
Synonyms	CPT1, CPT1-L, L-CPT1
Description	Carnitine palmitoyltransferase 1A (liver) (HGNC Symbol)
Entrez gene summary	The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.3
Chromosome location (bp)	68754620 - 68844410
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110090 (version 83.38)
Entrez gene	1374
UniProt	P50416 (UniProt - Evidence at protein level)
neXtProt	NX_P50416
Antibodypedia	CPT1A antibodies

PROTEIN BROWSER

CPT1A-001	CPT1A-002	CPT1A-004	CPT1A-006	CPT1A-007	CPT1A-008	CPT1A-009	CPT1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPT1A-001 ENSP00000439084 ENST00000540367	P50416 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0007623 [circadian rhythm] GO:0009437 [carnitine metabolic process] GO:0016020 [membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0030855 [epithelial cell differentiation] GO:0031307 [integral component of mitochondrial outer membrane] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	756 aa 86.2 kDa	No	2
CPT1A-002 ENSP00000446108 ENST00000539743	P50416 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform A0A024R5F4 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1A (Liver), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0007623 [circadian rhythm] GO:0009437 [carnitine metabolic process] GO:0016020 [membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0030855 [epithelial cell differentiation] GO:0031307 [integral component of mitochondrial outer membrane] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	773 aa 88.4 kDa	No	2
CPT1A-004 ENSP00000454332 ENST00000538994	H3BMD2 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	78 aa 9 kDa	No	0
CPT1A-006 ENSP00000265641 ENST00000265641	P50416 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform A0A024R5F4 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1A (Liver), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0006006 [glucose metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0006641 [triglyceride metabolic process] GO:0006853 [carnitine shuttle] GO:0007623 [circadian rhythm] GO:0009437 [carnitine metabolic process] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0030855 [epithelial cell differentiation] GO:0031307 [integral component of mitochondrial outer membrane] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0042493 [response to drug] GO:0042755 [eating behavior] GO:0042802 [identical protein binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046320 [regulation of fatty acid oxidation] GO:0050796 [regulation of insulin secretion] GO:0051260 [protein homooligomerization] GO:0071398 [cellular response to fatty acid] GO:1990698 [palmitoleoyltransferase activity] Show all	773 aa 88.4 kDa	No	2
CPT1A-007 ENSP00000457663 ENST00000561996	H3BUJ0 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.4 kDa	No	1
CPT1A-008 ENSP00000455116 ENST00000569129	H3BP22 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		118 aa 12.9 kDa	No	1
CPT1A-009 ENSP00000457826 ENST00000565318	H3BUV7 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] Show all	134 aa 14.8 kDa	No	2
CPT1A-201 ENSP00000365803 ENST00000376618	P50416 [Direct mapping] Carnitine O-palmitoyltransferase 1, liver isoform Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0007623 [circadian rhythm] GO:0009437 [carnitine metabolic process] GO:0016020 [membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0030855 [epithelial cell differentiation] GO:0031307 [integral component of mitochondrial outer membrane] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	756 aa 86.2 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.