Tissue expression of TMEM109 - Summary - The Human Protein Atlas

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TMEM109

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TMEM109
Gene description	Transmembrane protein 109
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression, including additional nuclear membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA011785
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TMEM109 (HGNC Symbol)
Synonyms	MGC5508
Description	Transmembrane protein 109 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60913874 - 60923443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110108 (version 83.38)
Entrez gene	79073
UniProt	Q9BVC6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVC6
Antibodypedia	TMEM109 antibodies

PROTEIN BROWSER

TMEM109-001	TMEM109-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM109-001 ENSP00000227525 ENST00000227525	Q9BVC6 [Direct mapping] Transmembrane protein 109 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005244 [voltage-gated ion channel activity] GO:0005515 [protein binding] GO:0005640 [nuclear outer membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0060548 [negative regulation of cell death] GO:0070062 [extracellular exosome] GO:0071480 [cellular response to gamma radiation] Show all	243 aa 26.2 kDa	Yes	4
TMEM109-003 ENSP00000443990 ENST00000536171	Q9BVC6 [Direct mapping] Transmembrane protein 109 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005244 [voltage-gated ion channel activity] GO:0005640 [nuclear outer membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0060548 [negative regulation of cell death] GO:0070062 [extracellular exosome] GO:0071480 [cellular response to gamma radiation] Show all	243 aa 26.2 kDa	Yes	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.