Tissue expression of FOLR3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FOLR3
Gene description	Folate receptor 3 (gamma)
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow)
GTEx:	Group enriched (spleen, kidney, lung)
FANTOM5:	Tissue enhanced (spleen, lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, kidney, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, lung)

GENE INFORMATION
Gene name	FOLR3 (HGNC Symbol)
Synonyms	FR-G
Description	Folate receptor 3 (gamma) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	72114869 - 72139892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110203 (version 83.38)
Entrez gene	2352
UniProt	P41439 (UniProt - Evidence at protein level)
neXtProt	NX_P41439
Antibodypedia	FOLR3 antibodies

PROTEIN BROWSER

FOLR3-002	FOLR3-003	FOLR3-004	FOLR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOLR3-002 ENSP00000481114 ENST00000611028	A0A087WXL1 [Direct mapping] Folate receptor gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		245 aa 27.9 kDa	Yes	0
FOLR3-003 ENSP00000481833 ENST00000622388	A0A087WYI3 [Direct mapping] Folate receptor gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 20.6 kDa	Yes	0
FOLR3-004 ENSP00000446279 ENST00000546166	F5H2G8 [Direct mapping] Folate receptor gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.2 kDa	Yes	0
FOLR3-201 ENSP00000411161 ENST00000442948	P41439 [Direct mapping] Folate receptor gamma Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005576 [extracellular region] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0019898 [extrinsic component of membrane] Show all	104 aa 11.8 kDa	Yes	0