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PANX1

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GENERAL INFORMATION

Gene name

 PANX1

Gene description

 Pannexin 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA016930
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA016930 A-431 Plasma membrane
HPA016930 U-2 OS Plasma membrane
HPA016930 U-251 MG Plasma membrane

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA016930

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Whole cells of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 29%33%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA016930 siRNA 1 U-2 OS
HPA016930 siRNA 2 U-2 OS
HPA016930 scrambled U-2 OS

GENE INFORMATION

Gene name

 PANX1 (HGNC Symbol)

Synonyms

 MRS1, PX1, UNQ2529

Description

 Pannexin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q21

Chromosome location (bp)

 94128928 - 94181972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110218 (version 83.38)

Entrez gene

 24145

UniProt

 Q96RD7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RD7

Antibodypedia

 PANX1 antibodies

PROTEIN BROWSER
PANX1-001
PANX1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PANX1-001
ENSP00000227638
ENST00000227638
Q96RD7 [Direct mapping]
Pannexin-1
A0A024R397 [Target identity:100%; Query identity:100%]
Pannexin
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0002931 [response to ischemia]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005243 [gap junction channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005921 [gap junction]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022840 [leak channel activity]
GO:0032059 [bleb]
GO:0033198 [response to ATP]
GO:0034214 [protein hexamerization]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050717 [positive regulation of interleukin-1 alpha secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0051015 [actin filament binding]
GO:0055077 [gap junction hemi-channel activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097110 [scaffold protein binding]
Show all
 426 aa
48 kDa 		No 4
PANX1-002
ENSP00000411461
ENST00000436171
Q96RD7 [Direct mapping]
Pannexin-1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005262 [calcium channel activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005921 [gap junction]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022840 [leak channel activity]
GO:0032059 [bleb]
GO:0034214 [protein hexamerization]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0055077 [gap junction hemi-channel activity]
GO:0070588 [calcium ion transmembrane transport]
Show all
 422 aa
47.6 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.