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Cancer tissues generally showed moderate to strong cytoplasmic and membranous immunoreactivity. Several lymphomas, testicular cancers and stomach cancers were negative.
Most cancer types displayed weak to moderate cytoplasmic, membrane or nuclear staining in a few cases. Strong immunoreactivity was observed in a few cases of gliomas and urothelial cancers.
Poliovirus receptor-related 1 (herpesvirus entry mediator C) (HGNC Symbol)
Entrez gene summary
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]