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MADD

GENERAL INFORMATION

Gene name

 MADD

Gene description

 MAP-kinase activating death domain

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA038568
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MADD (HGNC Symbol)

Synonyms

 DENN, KIAA0358, RAB3GEP

Description

 MAP-kinase activating death domain (HGNC Symbol)

Entrez gene summary

 Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47269161 - 47330031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110514 (version 83.38)

Entrez gene

 8567

UniProt

 Q8WXG6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXG6

Antibodypedia

 MADD antibodies

PROTEIN BROWSER
«
MADD-001
MADD-002
MADD-003
MADD-004
MADD-005
MADD-006
MADD-007
MADD-009
MADD-010
MADD-011
MADD-012
MADD-013
MADD-016
MADD-018
MADD-023
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MADD-001
ENSP00000343902
ENST00000342922
A0A0A0MRB5 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 1588 aa
176.6 kDa 		No 1
MADD-002
ENSP00000385585
ENST00000402799
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1545 aa
171.4 kDa 		No 1
MADD-003
ENSP00000384435
ENST00000406482
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1479 aa
164 kDa 		No 1
MADD-004
ENSP00000378745
ENST00000395336
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1581 aa
175.9 kDa 		No 1
MADD-005
ENSP00000304505
ENST00000349238
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1608 aa
178.6 kDa 		No 1
MADD-006
ENSP00000310933
ENST00000311027
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1647 aa
183.3 kDa 		No 1
MADD-007
ENSP00000384204
ENST00000407859
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1565 aa
173.4 kDa 		No 1
MADD-009
ENSP00000384287
ENST00000402192
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1587 aa
176.5 kDa 		No 1
MADD-010
ENSP00000388255
ENST00000453571
C9JM97 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 75 aa
8.7 kDa 		No 0
MADD-011
ENSP00000413116
ENST00000444117
C9K0L0 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
15.2 kDa 		No 0
MADD-012
ENSP00000398167
ENST00000428807
C9J6B0 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
 154 aa
17.4 kDa 		No 2
MADD-013
ENSP00000402364
ENST00000422579
C9JLZ9 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
15.2 kDa 		No 0
MADD-016
ENSP00000489300
ENST00000634938
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 199 aa
23 kDa 		No 0
MADD-018
ENSP00000384483
ENST00000405573
F8W8U2 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 439 aa
49.1 kDa 		No 0
MADD-023
ENSP00000378753
ENST00000395344
Q8WXG6 [Direct mapping]
MAP kinase-activating death domain protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016021 [integral component of membrane]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030295 [protein kinase activator activity]
GO:0032483 [regulation of Rab protein signal transduction]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0051726 [regulation of cell cycle]
GO:0097194 [execution phase of apoptosis]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001236 [regulation of extrinsic apoptotic signaling pathway]
Show all
 1541 aa
171 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.