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CARS

GENERAL INFORMATION

Gene name

 CARS

Gene description

 Cysteinyl-tRNA synthetase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Most abundant in exocrine pancreas and neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 6 antibodies.
HPA002383 , HPA002384 , CAB075734 , CAB075735 , CAB075736 , CAB075737
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CARS (HGNC Symbol)

Synonyms

 CARS1

Description

 Cysteinyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 3000922 - 3057613

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110619 (version 83.38)

Entrez gene

 833

UniProt

 P49589 (UniProt - Evidence at protein level)

neXtProt

 NX_P49589

Antibodypedia

 CARS antibodies

PROTEIN BROWSER
CARS-001
CARS-002
CARS-004
CARS-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CARS-001
ENSP00000380300
ENST00000397111
P49589 [Direct mapping]
Cysteine--tRNA ligase, cytoplasmic
A0A024RCG3 [Target identity:100%; Query identity:100%]
Cysteinyl-tRNA synthetase, isoform CRA_a
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004817 [cysteine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006423 [cysteinyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
Show all
 748 aa
85.5 kDa 		No 0
CARS-002
ENSP00000278224
ENST00000278224
P49589 [Direct mapping]
Cysteine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004817 [cysteine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006423 [cysteinyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
Show all
 726 aa
82.8 kDa 		No 0
CARS-004
ENSP00000369897
ENST00000380525
P49589 [Direct mapping]
Cysteine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004817 [cysteine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006423 [cysteinyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
Show all
 831 aa
94.6 kDa 		No 0
CARS-016
ENSP00000432619
ENST00000529772
B4DKY1 [Direct mapping]
Cysteine--tRNA ligase, cytoplasmic; cDNA FLJ59563, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16)
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004817 [cysteine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006423 [cysteinyl-tRNA aminoacylation]
Show all
 739 aa
84.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.