Expression of SLC22A18 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 22, member 18

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA067812	HPA071461

GENE INFORMATION
Gene name	SLC22A18 (HGNC Symbol)
Synonyms	BWR1A, BWSCR1A, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5
Description	Solute carrier family 22, member 18 (HGNC Symbol)
Entrez gene summary	This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	2899721 - 2925246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110628 (version 83.38)
Entrez gene	5002
UniProt	Q96BI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BI1
Antibodypedia	SLC22A18 antibodies

PROTEIN BROWSER

SLC22A18-001	SLC22A18-002	SLC22A18-003	SLC22A18-005	SLC22A18-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A18-001 ENSP00000311139 ENST00000312221	Q96BI1 [Direct mapping] Solute carrier family 22 member 18 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0007588 [excretion] GO:0015238 [drug transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015695 [organic cation transport] GO:0015893 [drug transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0055085 [transmembrane transport] Show all	424 aa 44.8 kDa	No	>9
SLC22A18-002 ENSP00000307859 ENST00000347936	Q96BI1 [Direct mapping] Solute carrier family 22 member 18 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0007588 [excretion] GO:0015238 [drug transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015695 [organic cation transport] GO:0015893 [drug transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0055085 [transmembrane transport] Show all	424 aa 44.8 kDa	No	>9
SLC22A18-003 ENSP00000369948 ENST00000380574	Q96BI1 [Direct mapping] Solute carrier family 22 member 18 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006855 [drug transmembrane transport] GO:0007588 [excretion] GO:0015238 [drug transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015695 [organic cation transport] GO:0015893 [drug transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0055085 [transmembrane transport] Show all	424 aa 44.8 kDa	No	>9
SLC22A18-005 ENSP00000392072 ENST00000449793	E9PRM7 [Direct mapping] Solute carrier family 22 member 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	326 aa 35 kDa	No	8
SLC22A18-012 ENSP00000433019 ENST00000485423	E9PMN7 [Direct mapping] Solute carrier family 22 member 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	134 aa 14.2 kDa	No	3